Corneal pain and experimental model development
نویسندگان
چکیده
منابع مشابه
Paroxetine Attenuates the Development and Existing Pain in a Rat Model of Neurophatic Pain
Background: P2X4 receptor (P2X4R), a purinoceptor expressed in activated spinal microglia, plays a key role in the pathogenesis of neuropathic pain. Spinal nerve injury induces up-regulation of P2X4R on activated microglia in the spinal cord, and blockade of this receptor can reduce neuropathic pain. The present study was undertaken to determine whether paroxetine, an inhibitor of P2X4R, could ...
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Central neuropathic pain (CNP) is considered as a complicated sensory disturbance which many multiple sclerosis (MS) patients suffer from. Although monophasic experimental autoimmune encephalomyelitis (EAE) mouse model is a gold standard model in preclinical research of MS, severe movement deficit could confound pain behaviors evaluation over the disease course. In this study, complete Freund&r...
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ژورنال
عنوان ژورنال: Progress in Retinal and Eye Research
سال: 2019
ISSN: 1350-9462
DOI: 10.1016/j.preteyeres.2018.11.005